Melvyn S. Soloff, Ph.D.Dr. Soloff

Professor, Obstetrics and Gynecology Scientist, Sealy Center for Molecular Medicine

 

Research Interests

The laboratory’s research focuses on oxytocin action, signaling by G protein coupled receptors, particularly the oxytocin receptor in human uterine smooth muscle, and regulation of gene expression in uterine smooth muscle and reproductive tissues.

Selected Publications

  1. Park ES, Echetebu CO, Soloff SL, Soloff MS. Oxytocin stimulation of RGS2 mRNA expression in cultured human myometrial cells. Am J Physiol 2002;282:E580-E584.
  2. Jeng Y-J, Soloff SL, Anderson GD, Soloff MS. Regulation of oxytocin receptor expression in cultured human myometrial cells. Endocrinology 2003; 144:61-68.
  3. Suarez VR, Park ES, Hankins GDV, Soloff MS. Expression of regulator of G protein signaling 2 (RGS2) in rat myometrium in pregnancy and parturition. Am J Obstet Gynecol 2003; 188:973-977.
  4. Soloff MS, Jeng Y-J. Oxytocin/vasopressin receptor signaling, In: Henry HL, Norman AW (eds.) Encyclopedia of Hormones and Related Cell Regulators. (PM Conn, Assoc. Ed.) Membrane Receptor Signal Transduction, Academic Press, NY, pp. 122-131; 2003.
  5. Hadsell DL, Bonnette S, George J, Torres D, Klementidis Y, Gao S, Haney PM, Sumy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M. Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of elongation 2 initiation factors 4E and 4G. Mol Endocrinol 2003;17:2251-2267.
  6. Soloff MS, Gal S, Hoare S, Peters CA, Hunzicker-Dunn M, Anderson GD, Wood TG. Cloning, characterization, and expression of the rat relaxin gene. Gene 2004; 323:149-155.
  7. Soloff MS, Cook, DL Jr, Jeng Y-J, Anderson GD. In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells. Endocrinology 2004;145:1248-1254.
  8. Soloff MS, Jeng Y-J. Ilies M, Soloff SL, Izban MG, Wood TG, Panova NI, Velagaleti GVN, Anderson GD. Immortalization and characterization of human myometrial cells from term-pregnant patients using a telomeraseexpression vector. Mol Hum Reprod 2004;10:685-695; .
  9. Soloff MS, Izban MG, Cook DL Jr, Jeng Y-J, Mifflin RC. Interleukin-1-induced NF-?B recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells. Mol Hum Reprod 12:619-624; 2006
  10. Jeng, Y-J, Suarez VR, Izban MG, Wang H-Q, Soloff MS. Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy, and signaling consequences, Am J Physiol Endocrinol Metab (in press, 2006).